Research Archive
A complete chronological list of our publications on mitochondrial genome integrity, copy-number control, and purifying selection.
2026
Mrx6 binds the Lon protease Pim1 N-terminal domain to confer selective substrate specificity and regulate mtDNA copy number
Schrott, S., Marafelli, I., Gerle, C., Bibinger, S., Bertgen, L., Marino, G., Schwenkert, S., Rathberger, R., Herrmann, J., Osman, C.#
Nucleic Acids Research 54(2): gkaf1390
Local mitochondrial physiology defined by mtDNA quality guides purifying selection
Thoma, F., Hagen, J., Rathberger, R., Padovani, F., Hörl, D., Schmoller, K., Osman, C.#
PLOS Genetics 22(1): e1011836
The mitochondrial cohibitin complex facilitates the biogenesis of inner membrane proteins
Kizmaz, B., Nutz, A., Hess, S., Hagen, J., Guerrero-Castillo, S., Cabrera-Orefice, A., Yoo, C., Osman, C., Räschle, M., Rhee, H., Herrmann, J.#
bioRxiv
mtHsp70 chaperone converts mitochondrial proteostasis stress into impaired protein import
Banerjee, R., Trauschke, V., Bertram, N., Aretz, I., Osman, C., Lamb, D.#, Mokranjac, D.#
Proceedings of the National Academy of Sciences of the United States of America 123(15): e2526136123
2025
Delayed protein translocation protects mitochondria against toxic CAT-tailed proteins
Bertram, N., Izawa, T., Thoma, F., Schwenkert, S., Duvezin-Caubet, S., Park, S., Wagener, N., Devin, A., Osman, C., Neupert, W., Mokranjac, D.#
Molecular Cell 85(21): 4082-4092
2024
Real-time assessment of mitochondrial DNA heteroplasmy dynamics at the single-cell level
Roussou, R., Metzler, D., Padovani, F., Thoma, F., Schwarz, R., Shraiman, B., Schmoller, K., Osman, C.#
The EMBO Journal 43(22): 5340-5359
Adaptive introgression of a visual preference gene
Rossi, M., Hausmann, A., Alcami, P., Moest, M., Roussou, R., Van Belleghem, S., Wright, D., Kuo, C., Lozano-Urrego, D., Maulana, A., Melo-Flórez, L., Rueda-Muñoz, G., McMahon, S., Linares, M., Osman, C., McMillan, W., Pardo-Diaz, C., Salazar, C., Merrill, R.#
Science 383(6689): 368-1373
2023
Two mitochondrial HMG-box proteins, Cim1 and Abf2, antagonistically regulate mtDNA copy number in Saccharomyces cerevisiae
Schrott, S., Osman, C.#
Nucleic Acids Research 51(21): 11813-11835
Regulation with cell size ensures mitochondrial DNA homeostasis during cell growth
Seel, A., Padovani, F., Mayer, M., Finster, A., Bureik, D., Thoma, F., Osman, C., Klecker, T., Schmoller, K.#
Nature Structural & Molecular Biology 30(10): 1549–1560
2022
Yme2, a putative RNA recognition motif and AAA+ domain containing protein, genetically interacts with the mitochondrial protein export machinery
Sharma, N., Osman, C.#
Biological Chemistry 403(8-9): 807-817
YeastMate: neural network-assisted segmentation of mating and budding events in Saccharomyces cerevisiae
Bunk, R., Moriasy, J., Thoma, F., Jakubke, C., Osman, C., Hörl, D.#
Bioinformatics 38(9): 2667–2669
An improved imaging system that corrects MS2-induced RNA destabilization
Li, W., Maekiniemi, A., Sato, H., Osman, C., Singer, R.#
Nature Methods 19: 1558–1562
2021
Reduced peroxisomal import triggers peroxisomal retrograde signaling
Rackles, E., Witting, M., Forné, I., Zhang, X., Zacherl, J., Schrott, S., Fischer, C., Ewbank, J., Osman, C., Imhof, A., Rolland, S.#
Cell Reports 34(3): 108653
Cristae-dependent quality control of the mitochondrial genome
Jakubke, C.*, Roussou, R.*, Maiser, A., Schug, C., Thoma, F., Bunk, R., Hörl, D., Leonhardt, H., Walter, P., Klecker, T., Osman, C.#
Science Advances 7(36): eabi8886
2020
Mrx6 regulates mitochondrial DNA copy number in Saccharomyces cerevisiae by engaging the evolutionarily conserved Lon protease Pim1
Göke, A., Schrott, S., Mizrak, A., Belyy, V., Osman, C.#, Walter, P.#
Molecular Biology of the Cell 31(7): 527-545
Power to the daughters - mitochondrial and mtDNA transmission during cell division
Aretz, I., Jakubke, C., Osman, C.#
Biological Chemistry 401(5): 533-546
2016
MICOS and phospholipid transfer by Ups2-Mdm35 organize membrane lipid synthesis in mitochondria
Aaltonen, M., Friedman, J., Osman, C., Salin, B., di Rago, J., Nunnari, J., Langer, T., Tatsuta, T.
Journal of Cell Biology 213(5): 525-34
2015
Integrity of the yeast mitochondrial genome, but not its distribution and inheritance, relies on mitochondrial fission and fusion
Osman, C., Noriega, T., Okreglak, V., Walter, P.
Proceedings of the National Academy of Sciences of the United States of America 112(9): E947–E956
2014
Specificity in endoplasmic reticulum-stress signaling in yeast entails a step-wise engagement of HAC1 mRNA to clusters of the stress sensor Ire1
van Anken, E., Pincus, D., Coyle, S., Aragón, T., Osman, C., Lari, F., Gómez Puerta, S., Korennykh, A., Walter, P.
Elife 3: e05031
2013
ER-associated mitochondrial division links the distribution of mitochondria and mitochondrial DNA in yeast
Murley, A., Lackner, L., Osman, C., West, M., Voeltz, G., Walter, P., Nunnari, J.
Elife 2: e00422
2011
The conserved GTPase Gem1 regulates endoplasmic reticulum-mitochondria connections
Kornmann, B., Osman, C., Walter, P.
Proceedings of the National Academy of Sciences of the United States of America 108(34): 14151-6
Making heads or tails of phospholipids in mitochondria
Osman, C., Voelker, D., Langer, T.
Journal of Cell Biology 192(1): 7-16
2010
Regulation of mitochondrial phospholipids by Ups1/PRELI-like proteins depends on proteolysis and Mdm35
Potting, C., Wilmes, C., Engmann, T., Osman, C., Langer, T.
The EMBO Journal 29(17): 2888-98
A mitochondrial phosphatase required for cardiolipin biosynthesis: the PGP phosphatase Gep4
Osman, C., Haag, M., Wieland, F., Brügger, B., Langer, T.
The EMBO Journal 29(12): 1976-87
2009
Prohibitins and the functional compartmentalization of mitochondrial membranes
Osman, C., Merkwirth, C., Langer, T.
Journal of Cell Science 122(21): 3823-30
The genetic interactome of prohibitins: coordinated control of cardiolipin and phosphatidylethanolamine by conserved regulators in mitochondria
Osman, C., Haag, M., Potting, C., Rodenfels, J., Dip, P., Wieland, F., Brügger, B., Westermann, B., Langer, T.
Journal of Cell Biology 184(4): 583-96
2007
Prohibitins interact genetically with Atp23, a novel processing peptidase and chaperone for the F1FO-ATP synthase
Osman, C., Wilmes, C., Tatsuta, T., Langer, T.
Molecular Biology of the Cell 18(2): 627-35