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mtDNA Intelligence Report

Automated curation of PubMed and bioRxiv literature focusing on mitochondrial genome organization, quality control, and yeast genetics.

Latest Report July 13, 2026

mtDNA Literature Briefing 2026-07-13

#mtDNA intel: • TOP1MT variant rs2293925 modulates mitochondrial R-loop dynamics in ALS iPSCs 🧬 • Urinary heteroplasmy screening outperforms blood testing for pathogenic mtDNA variants 🔬 • MIRO1-BAX complex acts as a key molecular checkpoint for neuronal cell death. #biotech …

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Academic Disclaimer: This briefing is synthesized by Gemini 1.5 Pro AI based on abstracts. Podcasts are generated with NotebookLM. While designed to assist in literature monitoring, AI can misinterpret nuanced biological data. Full credit belongs to the authors of the primary research; we strongly encourage readers to consult the original publications linked in each dossier to ensure accurate data interpretation.

Briefing Archive

Jul 09, 2026
#mtDNA intel: • TOP1MT rs2293925 variant regulates mitochondrial R-loop dynamics 🧬 • GSDMD-mtDNA-AIM2 axis drives neuronal pyroptosis post-brain injury • Biallelic ATP5ME loss-of-function causes severe …
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Jul 06, 2026
#mtDNA intel: • Deleterious heteroplasmy drives high-risk clonal hematopoiesis and blood malignancies. • LonP1 protease serves as a cardioprotective target against doxorubicin-induced cell death. • …
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Jul 02, 2026
#mtDNA intel: • Reassessment suggests human mtDNA methylation signals are technical artifacts 🧬 • DNM1L depletion drives m.10191C heteroplasmy shifting via ATG7 pathways 🔬 • …
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Jun 29, 2026
#mtDNA intel: • TALE-directed methyltransferase enables programmable mtDNA m5C modification linked to aging 🧬 • Prokaryotic Argonautes show DNA/RNA-guided activity in human mitochondria • DNM1L …
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Jun 25, 2026
#mtDNA intel: • Fibroblast Ca2+ overload drives skin fibrosis via mtDNA leakage & cGAS-STING 🧬 • Novel microprotein MASL identified from immune-associated mtDNA variant • …
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Jun 22, 2026
#mtDNA intel: • Lonp1 downregulation drives melanocyte pyroptosis via mitophagy suppression 🧬 • New patient-derived iPSC model established for MELAS m.3243A>G mutation • Environmental enrichment …
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Jun 18, 2026
#mtDNA intel: • Microhomology-mediated genome editing achieved via donor DNA delivery in human cells 🧬 • Runx1-Snx9 axis drives pathogenic mitochondrial vesicle secretion, activating cGAS-STING …
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Jun 15, 2026
#mtDNA intel: • STING1 senses mitochondrial damage to promote mitophagy 🧬 • Copper drives VDAC oligomerization, releasing mtDNA to trigger cell pyroptosis 🔬 • Novel …
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Jun 11, 2026
#mtDNA intel: • KAT7 epigenetic control of microglial mitochondrial immunity drives Alzheimer's pathology 🧬 • Nanotweezers track single-mitochondrion gene expression in live neurons 🔬 • …
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Jun 08, 2026
#mtDNA intel: • VDAC1-mediated mtDNA release drives cGAS-STING in T-cell inflammation 🧬 • COXFA4L3 represses mitochondrial DNA damage responses, promoting drug resistance • CPEO-causing mutations …
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Jun 04, 2026
#mtDNA intel: • Aspartate deficiency primes and amplifies cGAS-STING signaling in tumor models 🧬 • Mitochondrial OXPHOS directly restricts SARS-CoV-2 replication • Mitonuclear incompatibility remodels …
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Jun 01, 2026
#mtDNA intel: • PLSCR3 deficiency activates mtDNA-driven cGAS-STING to boost colorectal antitumor immunity 🧬 • Epithelial TFAM depletion drives progressive lung fibrosis • Taurine suppresses …
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May 28, 2026
#mtDNA intel: • Age-related mtDNA mutation pathways mapped in >750k human genomes 🧬 • MitoFLARE & EPG5 defects drive cGAS-STING immune activation in sepsis & …
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May 25, 2026
#mtDNA intel: • Cytosolic mtDNA release drives neuropathic pain via cGAS-STING-IRF3-CMPK2 signaling 🧬 • Mitochondrial activity directs nutrient uptake and patterning in human gastruloids • …
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May 21, 2026
#mtDNA intel: • CPT1A loss drives lung metastasis via mtDNA release & chronic STING activation 🧬 • CerS6 suppresses BNIP3 mitophagy, triggering mtDNA-STING/NLRP3 in lung …
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May 18, 2026
#mtDNA intel: • In vivo imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks 🧬 • Mechano-metabolic feedback connects tissue fluidity to mtDNA-dependent immunity in cancer …
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May 14, 2026
#mtDNA intel: • Single-molecule imaging tracks heteroplasmy dynamics through developmental bottlenecks 🧬 • Mechano-metabolic feedback links tissue fluidity to mtDNA-mediated cancer immunity 🔬 • IFI204-GSDMD …
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May 11, 2026
#mtDNA intel: • Membrane insertion of encoded proteins regulates ribosome decoding speed • TFAM organizes DNA into compact higher-order structures • MSTO1 modulates RAD51 to …
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May 07, 2026
#mtDNA intel: • BaDTF3 structure reveals mechanism for precision dsDNA deamination in mitochondrial genome editing. • Dopamine-driven mitochondrial dysfunction activates the cGAS-STING/IL-6 axis in macrophages. …
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May 04, 2026
#mtDNA intel: • SETD2 deficiency drives mtDNA leakage and BCL-XL dependency in #ccRCC 🧬 • IFN-α-mediated mitochondrial pore opening triggers mtRNA release in lupus models …
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Apr 30, 2026
#mtDNA intel: • Manganese and ER-mitochondrial contact sites identified as key regulators of mitochondrial DNA replication. • Long-read MitoScope mapping reveals tissue-specific somatic variations and …
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Apr 27, 2026
#mtDNA intel: • ER-mitochondrial contact sites and manganese regulate mtDNA replication • Membranes arrest the coarsening of mitochondrial condensates in human cells • mtDNA-cGAS/STING signaling …
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Apr 23, 2026
#mtDNA intel: • DHCR24 deficiency triggers cytosolic mtDNA-mediated cGAS-STING activation. • PolRMT and TFAM structural interactions define mitochondrial transcription regulation. • SLC25A48 promotes colorectal cancer …
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Apr 20, 2026
#mtDNA intel: • Mitochondrial translation elongation coordinates protein synthesis and folding to control OXPHOS biogenesis 🧬 • COX2-PGE2-PKA axis inhibits mtDNA-dependent STING activation to suppress …
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Apr 16, 2026
#mtDNA intel: • Structural mapping reveals PolRMT and TFAM coordination in promoter transcription. • MitoScope long-read analysis resolves tissue-specific somatic variation and nuclear-embedded sequences. • …
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Apr 13, 2026
#mtDNA intel: • Structural mapping of PolRMT-TFAM interactions defines promoter regulation 🧬 • ADT-OH mitigates cGAS-STING inflammatory cascades in microglia • Mitochondrial genomic variants identified …
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Apr 09, 2026
#mtDNA intel: • Scalable ESC platform enables efficient generation of mtDNA mutant mouse models 🧬 • COX2-PGE2-PKA axis suppresses antiviral immunity by inhibiting mtDNA-STING signaling …
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Apr 06, 2026
#mtDNA intel: • Membrane pearling drives nucleoid distribution in mammalian cells. • Identification of MTALTCO1, a novel 259-amino-acid protein encoded by the mitogenome. • Neuron-released …
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Apr 02, 2026
#mtDNA intel: • MitoPerturb-Seq maps single-cell responses to mtDNA depletion and heteroplasmy 🧬 • Autophagy and bottleneck size regulate purifying selection during maternal inheritance • …
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Mar 30, 2026
Structure-selective endonuclease drives uniparental inheritance mechanisms 🧬 • SCAD-mediated mtDNA leakage fuels antitumor immunity via demethylation • DCTPP1 regulates dCTP pool dynamics to maintain mtDNA …
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Mar 26, 2026
Core replication machinery organizes into multiphasic condensates • mtDNA variants influence nuclear telomere length 🧬 • UV irradiation alters TFAM binding specificity and DNA compaction …
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Mar 23, 2026
Structure-selective endonuclease drives uniparental mitochondrial inheritance. • Encapsulated mitochondrial transplantation reverses dysfunction in Parkinson's models 🧬. • VDAC1-mediated mtDNA release in keratinocytes triggers innate immunity …
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Mar 19, 2026
Single-cell multi-omics tracks mitochondrial mutational mosaicism dynamics. • RNA Pol III sensing of mtDNA is essential for IFN immunity against SARS-CoV-2. • Atpif1 drives CAR-T …
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Mar 16, 2026
AK4-mediated mtDNA synthesis regulates macrophage anti-bacterial activity. • PARKIN overexpression confers cardioprotection via mtDNA-cGAS-STING axis suppression. • Erythrocyte TLR9-ox-mtDNA binding links oxidative damage to systemic …
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Mar 15, 2026
4 mt-tRNAs expressed from 2 loci • TLR9-ox-mtDNA binding drives MS inflammation • Butyrate extends life in mitochondrial deficiency 🧬🔬 #cellbio
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