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mtDNA Intelligence Report

Automated curation of PubMed and bioRxiv literature focusing on mitochondrial genome organization, quality control, and yeast genetics.

Latest Report May 28, 2026

mtDNA Literature Briefing 2026-05-28

#mtDNA intel: • Age-related mtDNA mutation pathways mapped in >750k human genomes 🧬 • MitoFLARE & EPG5 defects drive cGAS-STING immune activation in sepsis & neurodegeneration • NAD+ enhances SIRT2-modulated microtubule dynamics to rescue mitophagy 🔬 #Mitochondria #CellBiology
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Academic Disclaimer: This briefing is synthesized by Gemini 1.5 Pro AI based on abstracts. Podcasts are generated with NotebookLM. While designed to assist in literature monitoring, AI can misinterpret nuanced biological data. Full credit belongs to the authors of the primary research; we strongly encourage readers to consult the original publications linked in each dossier to ensure accurate data interpretation.

Briefing Archive

May 25, 2026
#mtDNA intel: • Cytosolic mtDNA release drives neuropathic pain via cGAS-STING-IRF3-CMPK2 signaling 🧬 • Mitochondrial activity directs nutrient uptake and patterning in human gastruloids • …
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May 21, 2026
#mtDNA intel: • CPT1A loss drives lung metastasis via mtDNA release & chronic STING activation 🧬 • CerS6 suppresses BNIP3 mitophagy, triggering mtDNA-STING/NLRP3 in lung …
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May 18, 2026
#mtDNA intel: • In vivo imaging reveals heteroplasmy dynamics shaped by developmental bottlenecks 🧬 • Mechano-metabolic feedback connects tissue fluidity to mtDNA-dependent immunity in cancer …
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May 14, 2026
#mtDNA intel: • Single-molecule imaging tracks heteroplasmy dynamics through developmental bottlenecks 🧬 • Mechano-metabolic feedback links tissue fluidity to mtDNA-mediated cancer immunity 🔬 • IFI204-GSDMD …
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May 11, 2026
#mtDNA intel: • Membrane insertion of encoded proteins regulates ribosome decoding speed • TFAM organizes DNA into compact higher-order structures • MSTO1 modulates RAD51 to …
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May 07, 2026
#mtDNA intel: • BaDTF3 structure reveals mechanism for precision dsDNA deamination in mitochondrial genome editing. • Dopamine-driven mitochondrial dysfunction activates the cGAS-STING/IL-6 axis in macrophages. …
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May 04, 2026
#mtDNA intel: • SETD2 deficiency drives mtDNA leakage and BCL-XL dependency in #ccRCC 🧬 • IFN-α-mediated mitochondrial pore opening triggers mtRNA release in lupus models …
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Apr 30, 2026
#mtDNA intel: • Manganese and ER-mitochondrial contact sites identified as key regulators of mitochondrial DNA replication. • Long-read MitoScope mapping reveals tissue-specific somatic variations and …
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Apr 27, 2026
#mtDNA intel: • ER-mitochondrial contact sites and manganese regulate mtDNA replication • Membranes arrest the coarsening of mitochondrial condensates in human cells • mtDNA-cGAS/STING signaling …
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Apr 23, 2026
#mtDNA intel: • DHCR24 deficiency triggers cytosolic mtDNA-mediated cGAS-STING activation. • PolRMT and TFAM structural interactions define mitochondrial transcription regulation. • SLC25A48 promotes colorectal cancer …
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Apr 20, 2026
#mtDNA intel: • Mitochondrial translation elongation coordinates protein synthesis and folding to control OXPHOS biogenesis 🧬 • COX2-PGE2-PKA axis inhibits mtDNA-dependent STING activation to suppress …
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Apr 16, 2026
#mtDNA intel: • Structural mapping reveals PolRMT and TFAM coordination in promoter transcription. • MitoScope long-read analysis resolves tissue-specific somatic variation and nuclear-embedded sequences. • …
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Apr 13, 2026
#mtDNA intel: • Structural mapping of PolRMT-TFAM interactions defines promoter regulation 🧬 • ADT-OH mitigates cGAS-STING inflammatory cascades in microglia • Mitochondrial genomic variants identified …
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Apr 09, 2026
#mtDNA intel: • Scalable ESC platform enables efficient generation of mtDNA mutant mouse models 🧬 • COX2-PGE2-PKA axis suppresses antiviral immunity by inhibiting mtDNA-STING signaling …
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Apr 06, 2026
#mtDNA intel: • Membrane pearling drives nucleoid distribution in mammalian cells. • Identification of MTALTCO1, a novel 259-amino-acid protein encoded by the mitogenome. • Neuron-released …
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Apr 02, 2026
#mtDNA intel: • MitoPerturb-Seq maps single-cell responses to mtDNA depletion and heteroplasmy 🧬 • Autophagy and bottleneck size regulate purifying selection during maternal inheritance • …
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Mar 30, 2026
Structure-selective endonuclease drives uniparental inheritance mechanisms 🧬 • SCAD-mediated mtDNA leakage fuels antitumor immunity via demethylation • DCTPP1 regulates dCTP pool dynamics to maintain mtDNA …
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Mar 26, 2026
Core replication machinery organizes into multiphasic condensates • mtDNA variants influence nuclear telomere length 🧬 • UV irradiation alters TFAM binding specificity and DNA compaction …
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Mar 23, 2026
Structure-selective endonuclease drives uniparental mitochondrial inheritance. • Encapsulated mitochondrial transplantation reverses dysfunction in Parkinson's models 🧬. • VDAC1-mediated mtDNA release in keratinocytes triggers innate immunity …
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Mar 19, 2026
Single-cell multi-omics tracks mitochondrial mutational mosaicism dynamics. • RNA Pol III sensing of mtDNA is essential for IFN immunity against SARS-CoV-2. • Atpif1 drives CAR-T …
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Mar 16, 2026
AK4-mediated mtDNA synthesis regulates macrophage anti-bacterial activity. • PARKIN overexpression confers cardioprotection via mtDNA-cGAS-STING axis suppression. • Erythrocyte TLR9-ox-mtDNA binding links oxidative damage to systemic …
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Mar 15, 2026
4 mt-tRNAs expressed from 2 loci • TLR9-ox-mtDNA binding drives MS inflammation • Butyrate extends life in mitochondrial deficiency 🧬🔬 #cellbio
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