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mtDNA Intelligence Report

Automated curation of PubMed and bioRxiv literature focusing on mitochondrial genome organization, quality control, and yeast genetics.

Latest Report April 09, 2026

mtDNA Literature Briefing 2026-04-09

#mtDNA intel: • Scalable ESC platform enables efficient generation of mtDNA mutant mouse models 🧬 • COX2-PGE2-PKA axis suppresses antiviral immunity by inhibiting mtDNA-STING signaling • MitoEdit pipeline optimizes mtDNA base editing and predicts bystander effects 🔬 #CellBio #Genetics #Immunity
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Academic Disclaimer: This briefing is synthesized by Gemini 1.5 Pro AI based on abstracts. Podcasts are generated with NotebookLM. While designed to assist in literature monitoring, AI can misinterpret nuanced biological data. Full credit belongs to the authors of the primary research; we strongly encourage readers to consult the original publications linked in each dossier to ensure accurate data interpretation.

Briefing Archive

Apr 06, 2026
#mtDNA intel: • Membrane pearling drives nucleoid distribution in mammalian cells. • Identification of MTALTCO1, a novel 259-amino-acid protein encoded by the mitogenome. • Neuron-released …
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Apr 02, 2026
#mtDNA intel: • MitoPerturb-Seq maps single-cell responses to mtDNA depletion and heteroplasmy 🧬 • Autophagy and bottleneck size regulate purifying selection during maternal inheritance • …
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Mar 30, 2026
Structure-selective endonuclease drives uniparental inheritance mechanisms 🧬 • SCAD-mediated mtDNA leakage fuels antitumor immunity via demethylation • DCTPP1 regulates dCTP pool dynamics to maintain mtDNA …
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Mar 26, 2026
Core replication machinery organizes into multiphasic condensates • mtDNA variants influence nuclear telomere length 🧬 • UV irradiation alters TFAM binding specificity and DNA compaction …
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Mar 23, 2026
Structure-selective endonuclease drives uniparental mitochondrial inheritance. • Encapsulated mitochondrial transplantation reverses dysfunction in Parkinson's models 🧬. • VDAC1-mediated mtDNA release in keratinocytes triggers innate immunity …
Dossier Audio
Mar 19, 2026
Single-cell multi-omics tracks mitochondrial mutational mosaicism dynamics. • RNA Pol III sensing of mtDNA is essential for IFN immunity against SARS-CoV-2. • Atpif1 drives CAR-T …
Dossier Audio
Mar 16, 2026
AK4-mediated mtDNA synthesis regulates macrophage anti-bacterial activity. • PARKIN overexpression confers cardioprotection via mtDNA-cGAS-STING axis suppression. • Erythrocyte TLR9-ox-mtDNA binding links oxidative damage to systemic …
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Mar 15, 2026
4 mt-tRNAs expressed from 2 loci • TLR9-ox-mtDNA binding drives MS inflammation • Butyrate extends life in mitochondrial deficiency 🧬🔬 #cellbio
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