mtDNA Copy Number Regulation

Each cell contains multiple copies of mitochondrial DNA, and maintaining the correct number of genomes is essential for proper mitochondrial function. Too few copies can limit energy production, while uncontrolled expansion can disrupt mitochondrial organization and cellular homeostasis. Our work explores the molecular mechanisms that regulate mtDNA copy number and nucleoid composition. In particular, we study how mitochondrial proteins coordinate genome replication, nucleoid architecture, and cellular physiology to maintain appropriate mtDNA abundance across different growth conditions.